Institut d'Investigació Sanitària Illes Balears (IdISBa) Research Group.

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Interplay between Peptidoglycan Biology and Virulence in Gram-Negative Pathogens.

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September 14, 2018

Juan C1, Torrens G1, Barceló IM1, Oliver A1 1Hospital Universitario Son Espases,Palma de Mallorca,Spain. The clinical and epidemiological threat of the growing antimicrobial resistance in Gram-negative pathogens, particularly for β-lactams, the most frequently used and relevant antibiotics, urges research to find new therapeutic weapons to combat the infections caused by these microorganisms. An essential previous… Read More ›

Deciphering β-lactamase-independent β-lactam resistance evolution trajectories in Pseudomonas aeruginosa.

Cabot G1, Florit-Mendoza L1, Sánchez-Diener I1, Zamorano L1, Oliver A1 1Hospital Universitario Son Espases,Palma de Mallorca,Spain. Background:While resistance related to the expression of β-lactamases, such as AmpC from Pseudomonas aeruginosa, has been deeply studied, this work addresses the gap in the knowledge of other potential bacterial strategies to overcome the activity of β-lactams when β-lactamases… Read More ›

Comparison of Predictors and Mortality Between Bloodstream Infections Caused by ESBL-Producing Escherichia coli and ESBL-Producing Klebsiella pneumoniae.

Scheuerman O1, Schechner V1, Carmeli Y1, Gutiérrez-Gutiérrez B2, Calbo E3, Almirante B4, Viale PL5, Oliver A6, Ruiz-Garbajosa P7, Gasch O8Gozalo M9, Pitout J10, Akova M11, Peña C12, Molina J13, Hernández-Torres A14, Venditti M15, Prim N16, Origüen J17, Bou G18, Tacconelli E19, Tumbarello M20, Hamprecht A21, Karaiskos I22, de la Calle C23, Pérez F24, Schwaber MJ1,… Read More ›

Optimization of a meropenem plus tobramycin combination dosage regimen against hypermutable and non-hypermutable Pseudomonas aeruginosa via mechanism-based modeling and the hollow-fiber infection model.

Landersdorfer CB1,2, Rees VE3,2, Yadav R3, Rogers KE3,2, Kim TH4, Bergen PJ2, Cheah SE3, Boyce JD5, Peleg AY5,6, Oliver A7, Shin BS4, Nation RL3, Bulitta JB8. 1 Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia cornelia.landersdorfer@monash.edu. 2 Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash… Read More ›

Evolution of the Pseudomonas aeruginosa aminoglycoside mutational resistome in vitro and in the cystic fibrosis setting.

López-Causapé C1, Rubio R2, Cabot G2, Oliver A2. 1 Servicio de Microbiología and Unidad de Investigación, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria de las Islas Baleares (IdISBa), Palma de Mallorca, Spain. carla.lopez@ssib.es. 2 Servicio de Microbiología and Unidad de Investigación, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria de las Islas Baleares (IdISBa),… Read More ›

Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy.

Mensa J1, Barberán J2, Soriano A1, Llinares P3, Marco F4, Cantón R5, Bou G6, González Del Castillo J7, Maseda E8, Azanza JR9, Pasquau J10, García-Vidal C1, Reguera JM11, Sousa D3, Gómez J12, Montejo M13, Borges M14, Torres A15, Alvarez-Lerma F16, Salavert M17, Zaragoza R18, Oliver A19. 1Servicio de Enfermedades Infecciosas, Hospital Clinic, Barcelona, Spain 2Servicio… Read More ›

Evaluation of Ceftolozane-Tazobactam in Combination with Meropenem against Pseudomonas aeruginosa ST175 in a Hollow-Fiber Infection Model.

Montero M1, VanScoy BD2, López-Causapé C3, Conde H2, Adams J2, Segura C4, Zamorano L3, Oliver A3, Horcajada JP5, Ambrose PG2,6. 1Infectious Diseases Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d’ Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra Barcelona, Spain. 2Institute for Clinical Pharmacodynamics,… Read More ›