Antibiotic Resistance and Pathogenicity of Bacterial Infections Research Group
Research group of the Health Research Institute of the Balearic Islands (IdiSBa, Group information). Founded in 2002 and accredited as a competitive research group by the Autonomous Community of the Balearic Islands, the group is composed of basic and clinical researchers from the Son Espases University Hospital (HUSE, Service information) from various specialties, with extensive experience and a long-standing collaborative trajectory in the field of infectious disease research.
The group is part of the Consorcio Centro de Investigación Biomédica en Red (CIBER) in Infectious Diseases (CIBERINFEC) of the Carlos III Health Institute (ISCIII).
Latest news
In vitro potentiation of tetracyclines in Pseudomonas aeruginosa by RW01, a new cyclic peptide.
Roson-Calero N; Gomis Font MA; Ruiz-Soriano A; Just-Baringo X; Pachón-Ibáñez ME; Salvador JP; Marco MP; Giralt E; Oliver A; Ballesté-Delpierre C; Vila J Abstract: The pipeline for new drugs against multidrug-resistant Pseudomonas aeruginosa remains limited, highlighting the urgent need for innovative treatments. New strategies, such as membrane-targeting molecules acting as adjuvants, aim to enhance antibiotic effectiveness and combat resistance. RW01,...
Impact of Pseudomonas aeruginosa carriage on intensive care unit-acquired pneumonia: a European multicentre prospective cohort study.
Recanatini C; van Werkhoven CH; van der Schalk TE; Paling F; Hazard D; Timbermont L; Torrens G; DiGiandomenico A; Esser MT; Wolkewitz M; Sifakis F; Goossens H; Bonten M; Oliver A; Malhotra-Kumar S; Kluytmans J Abstract: Pseudomonas aeruginosa (PA) is a common causative pathogen of pneumonia acquired in the intensive care unit (ICU). The aim of this study was to...
A multirange paper-based analytical device for identifying low, moderate, and high P. aeruginosa bacterial loads in sputum samples.
Adrover-Jaume C; Clemente A; Viana-Ramírez J; Rojo-Molinero E; Oliver A; de la Rica R Abstract: In this article we introduce a multirange analytical device that extends the dynamic range of nanoparticle-based immunoassays thanks to a multisensor design. Multirange devices contain low- and high-range sensors in the same analytical platform. The low-range sensor defines the limit of detection and quantifies low...
Functional and structural analyses of amino acid sequence variation in PDC β-lactamase reveal different mechanistic pathways toward cefiderocol resistance in Pseudomonas aeruginosa.
González-Pinto L; Gomis-Font MA; Lence E; Outeda-García M; Blanco-Martín T; Rodríguez-Pallares S; Sánchez-Peña L; Alonso-García I; Vázquez-Ucha JC; Beceiro A; Bou G; González-Bello C; Oliver A; Arca-Suárez J Abstract: A wide variety of clinically observed amino acid alterations in the Pseudomonas aeruginosa chromosomal β-lactamase AmpC (Pseudomonas-derived cephalosporinase [PDC]) are associated with increased resistance to cefepime, ceftolozane/tazobactam, or ceftazidime/avibactam, but their...
Management of multidrug-resistant gram-negative bacilli infections in adult solid organ transplant recipients: GESITRA-IC/SEIMC, CIBERINFEC, and SET recommendations update.
Rodríguez-Goncer I; Ruiz-Arabi E; Herrera S; Sabé N; Los-Arcos I; Silva JT; Pérez-Nadales E; Machuca I; Álvarez R; Valerio M; Castón JJ; Aguilera V; Bodro M; Cano Á; Cantón R; Carmona P; Carratalà J; Cordero E; Cruzado JM; Fariñas MC; Fernández-Ruiz M; Fondevila C; Fortún J; García-Cosío MD; Gutiérrez-Dalmau A; Iturbe D; Justo I; Len O; López-Medrano F; López Oliva...
Effects of different resistance mechanisms on bacterial response to meropenem, ciprofloxacin, and their combination described by next-generation mechanism-based modelling.
Terrill AE; Tait JR; Rogers KE; Lee WL; López-Causapé C; Wang X; Song J; Nation RL; Oliver A; Landersdorfer CB Abstract: This study aimed to investigate the effects of different bacterial resistance mechanisms on the response of isogenic strains of Pseudomonas aeruginosa to meropenem and ciprofloxacin, in monotherapy and combination. Seven isogenic P. aeruginosa strains were used: the PAO1 wild-type...