Antibiotic Resistance and Pathogenicity of Bacterial Infections Research Group
Research group of the Health Research Institute of the Balearic Islands (IdiSBa, Group information). Founded in 2002 and accredited as a competitive research group by the Autonomous Community of the Balearic Islands, the group is composed of basic and clinical researchers from the Son Espases University Hospital (HUSE, Service information) from various specialties, with extensive experience and a long-standing collaborative trajectory in the field of infectious disease research.
The group is part of the Consorcio Centro de Investigación Biomédica en Red (CIBER) in Infectious Diseases (CIBERINFEC) of the Carlos III Health Institute (ISCIII).
Latest news
A multirange paper-based analytical device for identifying low, moderate, and high P. aeruginosa bacterial loads in sputum samples.
Adrover-Jaume C; Clemente A; Viana-Ramírez J; Rojo-Molinero E; Oliver A; de la Rica R Abstract: In this article we introduce a multirange analytical device that extends the dynamic range of nanoparticle-based immunoassays thanks to a multisensor design. Multirange devices contain low- and high-range sensors in the same analytical platform. The low-range sensor defines the limit of detection and quantifies low...
In vitro potentiation of tetracyclines in Pseudomonas aeruginosa by RW01, a new cyclic peptide.
Roson-Calero N; Gomis Font MA; Ruiz-Soriano A; Just-Baringo X; Pachón-Ibáñez ME; Salvador JP; Marco MP; Giralt E; Oliver A; Ballesté-Delpierre C; Vila J Abstract: The pipeline for new drugs against multidrug-resistant Pseudomonas aeruginosa remains limited, highlighting the urgent need for innovative treatments. New strategies, such as membrane-targeting molecules acting as adjuvants, aim to enhance antibiotic effectiveness and combat resistance. RW01,...
Impact of Pseudomonas aeruginosa carriage on intensive care unit-acquired pneumonia: a European multicentre prospective cohort study.
Recanatini C; van Werkhoven CH; van der Schalk TE; Paling F; Hazard D; Timbermont L; Torrens G; DiGiandomenico A; Esser MT; Wolkewitz M; Sifakis F; Goossens H; Bonten M; Oliver A; Malhotra-Kumar S; Kluytmans J Abstract: Pseudomonas aeruginosa (PA) is a common causative pathogen of pneumonia acquired in the intensive care unit (ICU). The aim of this study was to...
Ceftazidime-avibactam use selects multidrug-resistance and prevents designing collateral sensitivity-based therapies against Pseudomonas aeruginosa.
Hernando-Amado S; Gomis-Font MA; Valverde JR; Oliver A; Martínez JL Abstract: Ceftazidime-avibactam is a β-lactam/β-lactamase inhibitor combination restricted for the treatment of multidrug-resistant infections of Pseudomonas aeruginosa non-susceptible to ceftazidime and resistant to carbapenems. Crucially, it has not been studied if its use could allow the design or application of new or stablished evolution-based strategies that exploit the increased susceptibility...
Whole Genome Sequencing Analysis of Klebsiella pneumoniae Isolates from Health Care-Associated Bacteremia of Urinary Origin in Spain: Findings from the Multicenter ITUBRAS-2 Cohort Study.
Becerra-Aparicio F; Gómez-Zorrilla S; Hernández-García M; Xanthopoulou K; Gijón D; Siverio A; Berbel D; Cercenado E; Rivera A; De Malet A; Xercavins M; Ruiz De Gopegui E; Canoura-Fernández L; Martínez JA; Seral C; Del Pozo JL; Cotarelo M; Ponz R; Higgins PG; Durán-Jordà X; Cantón R; Oliver A; Horcajada JP; Ruiz-Garbajosa P Abstract: The objective of this study was to...
Pseudomonas aeruginosa chronic infections in patients with bronchiectasis: a silent reservoir of carbapenemase-producing epidemic high-risk clones.
Muñoz-Santa A; López-Causapé C; Bellés A; Gómez-Arbonés X; Cortés-Lara S; García-González M; Pifarré-Teixidó R; Oliver A Abstract: Pseudomonas aeruginosa is one of the major drivers of morbidity and mortality in patients with chronic underlying diseases. Whereas cystic fibrosis (CF) P. aeruginosa strains have been well studied, non-CF bronchiectasis isolates have received less scientific attention. We determined the antibiotic susceptibility profiles...