Antibiotic Resistance and Pathogenicity of Bacterial Infections Research Group
Research group of the Health Research Institute of the Balearic Islands (IdiSBa, Group information). Founded in 2002 and accredited as a competitive research group by the Autonomous Community of the Balearic Islands, the group is composed of basic and clinical researchers from the Son Espases University Hospital (HUSE, Service information) from various specialties, with extensive experience and a long-standing collaborative trajectory in the field of infectious disease research.
The group is part of the Consorcio Centro de Investigación Biomédica en Red (CIBER) in Infectious Diseases (CIBERINFEC) of the Carlos III Health Institute (ISCIII).
Latest news
A multirange paper-based analytical device for identifying low, moderate, and high P. aeruginosa bacterial loads in sputum samples.
Adrover-Jaume C; Clemente A; Viana-Ramírez J; Rojo-Molinero E; Oliver A; de la Rica R Abstract: In this article we introduce a multirange analytical device that extends the dynamic range of nanoparticle-based immunoassays thanks to a multisensor design. Multirange devices contain low- and high-range sensors in the same analytical platform. The low-range sensor defines the limit of detection and quantifies low...
In vitro potentiation of tetracyclines in Pseudomonas aeruginosa by RW01, a new cyclic peptide.
Roson-Calero N; Gomis Font MA; Ruiz-Soriano A; Just-Baringo X; Pachón-Ibáñez ME; Salvador JP; Marco MP; Giralt E; Oliver A; Ballesté-Delpierre C; Vila J Abstract: The pipeline for new drugs against multidrug-resistant Pseudomonas aeruginosa remains limited, highlighting the urgent need for innovative treatments. New strategies, such as membrane-targeting molecules acting as adjuvants, aim to enhance antibiotic effectiveness and combat resistance. RW01,...
Impact of Pseudomonas aeruginosa carriage on intensive care unit-acquired pneumonia: a European multicentre prospective cohort study.
Recanatini C; van Werkhoven CH; van der Schalk TE; Paling F; Hazard D; Timbermont L; Torrens G; DiGiandomenico A; Esser MT; Wolkewitz M; Sifakis F; Goossens H; Bonten M; Oliver A; Malhotra-Kumar S; Kluytmans J Abstract: Pseudomonas aeruginosa (PA) is a common causative pathogen of pneumonia acquired in the intensive care unit (ICU). The aim of this study was to...
An antisense peptide-conjugated peptide nucleic acid (PPNA) for peptidoglycan recycling inhibition reduces AmpC hyperproduction and β-lactam resistance in Pseudomonas aeruginosa.
Escobar-Salom M; Barceló IM; Sansó-Sastre J; Torrens G; Jordana-Lluch E; Moyà B; Oliver A; Juan C Abstract: We performed a proof-of-concept study to validate a peptide-conjugated peptide nucleic acid (PPNA) directed to inhibit peptidoglycan recycling as strategy to reduce AmpC hyperproduction and β-lactam resistance in Pseudomonas aeruginosa. Our nagZ-targeting PPNA at 2 µM decreased mRNA levels of nagZ and ampC...
Pharmacodynamic interaction of apotransferrin and anti-pseudomonal antibiotics against extensively drug-resistant Pseudomonas aeruginosa in a dynamic PK/PD model.
Montero MM; Domene-Ochoa S; Prim N; López-Causapé C; Echeverria-Esnal D; Sorlí L; Luque S; Padilla E; Grau S; Oliver A; Horcajada JP Abstract: The rise of antibiotic resistance in clinical settings poses a major challenge. Apotransferrin has emerged as a potential non-traditional therapy for combating infections, potentially preventing resistance development while enhancing bactericidal effects. This study evaluated the efficacy of...
Spanish nationwide survey of Pseudomonas aeruginosa cefiderocol susceptibility and resistance mechanisms.
Sastre-Femenia MÀ; Fernández-Muñoz A; Gomis-Font MA; Taltavull B; López-Causapé C; Arca-Suárez J; Martínez-Martínez L; Cantón R; Larrosa N; Oteo-Iglesias J; Oliver A Abstract: Cefiderocol is a new siderophore-cephalosporin showing potent activity against Pseudomonas aeruginosa, including isolates showing extensively drug-resistant (XDR) or difficult-to-treat resistant (DTR) phenotypes. However, there is still a limited understanding of the potential resistance mechanisms. The objective of...