Institut d'Investigació Sanitària Illes Balears (IdISBa) Research Group.

Research areas

Main research lines of our group are:

  • Molecular mechanisms and epidemiology of antimicrobial resistance.
    • Transferable beta-lactamase mediated resistance, particularly Extended Spectrum Beta-Lactamases (ESBL) and carbapenemases in Enterobacteriaceae and Pseudomonas aeruginosa. Meticillin Resistant Staphilococcus aureus (MRSA) and Clostridium difficile.
    • Chromosomal resistance: mechanisms, regulation, dynamics and factors determining resitance development. Detection and evaluation of new therapeutic targets to fight resistance mechanism, specially those mediated by chromosomally encoded AmpC beta-lactamase. Virulence-Resistance relationships.
    • New antibiotic development and testing, in collaboration with Pharmaceutical Industry.
  • Immunity and Infection.
    • Pathogen-host interactions, using Klebsiella pneumoniae, Streptococcus pyogenes and Pseudomonas aeruginosa models.
  • Chronic Bacterial Infections.
    • Chronic bacterial infection epidemiology in Cystic Fibrosis, Bronchiectasis and COPD (Chronic Obstructive Pulmonary Disease) pacients.
    • Pathogenesis of chronic bacterial infections.
    • Bacterial adaptation mechanisms, persistence determinants of chronic infections. Hypermutation mechanisms in adaptation to chronic infections and antibiotic resistance development.
    • Therapeutic strategies development to fight chronic pulmonary infections, including biofilms and in vivo models.
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