Selection of AmpC β-Lactamase Variants and Metallo-β-Lactamases Leading to Ceftolozane/Tazobactam and Ceftazidime/Avibactam Resistance during Treatment of MDR/XDR Pseudomonas aeruginosa Infections
Ruedas-López Alba; Alonso-García Isaac; Lasarte-Monterrubio Cristina; Guijarro-Sánchez Paula; Gato Eva; Vázquez-Ucha Juan Carlos; Vallejo Juan Andrés; Fraile-Ribot Pablo Arturo; Fernández-Pérez Begoña; Velasco David; Gutiérrez-Urbón José María; Oviaño Marina; Beceiro Alejandro; González-Bello Concepción; Oliver Antonio; Arca-Suárez Jorge; Bou Germán
Abstract: Infections caused by ceftolozane-tazobactam and ceftazidime-avibactam-resistant P. aeruginosa infections are an emerging concern. We aimed to analyze the underlying ceftolozane-tazobactam and ceftazidime-avibactam resistance mechanisms in all multidrug-resistant or extensively drug-resistant (MDR/XDR) P. aeruginosa isolates recovered during 1 year (2020) from patients with a documented P. aeruginosa infection. Antimicrobial Agents and Chemotherapy: 2022 doi: 10.1128/AAC.02067-21 https://doi.org/doi: 10.1128/AAC.02067-21