In Vivo Evolution of GES β-Lactamases Driven by Ceftazidime/Avibactam Treatment of Pseudomonas aeruginosa Infections
Fraile-Ribot Pablo A.; Fernández Javier; Gomis-Font María A.; Forcelledo Lorena; Mulet Xavier; López-Causapé Carla; Oliver Antonio
Abstract: The mechanisms underlying an in vivo switch in the resistance phenotype of P. aeruginosa after ceftazidime-avibactam treatment was investigated. The initial isolate (a blood culture) was resistant to meropenem but remained susceptible to antipseudomonal cephalosporins and combinations with β-lactamase inhibitors. Antimicrobial Agents and Chemotherapy: 2021 doi: 10.1128/AAC.00986-21 https://doi.org/doi: 10.1128/AAC.00986-21